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Drug – Drug Interactions Food-drug Interaction

The administration of one drug (A) can alter the action of another (B) by one of two general mechanisms: • Modification of the pharmacological effect of B without altering its concentration in the tissue fluid (pharmacodynamic interaction) • Alteration of the concentration of B that reaches its site of action (pharmacokinetic interaction). 1) For such interactions to be important clinically it is necessary that the therapeutic range of drug B is narrow (i.e. that a small reduction in effect will lead to loss of efficacy and/or a small increase in effect will lead to toxicity). 2) For pharmacokinetic interactions to be clinically important it is also necessary that the dose-response curve of drug B is steep (so that a small change in plasma concentration leads to a substantial change in effect). 3) For many drugs these conditions are not met: even quite large changes in plasma concentrations of relatively non-toxic drugs like penicillin are unlikely to give rise to clinical problems because there is usually a comfortable safety margin between plasma concentrations produced by usual doses and those resulting in either loss of efficacy or toxicity. 4) Several drugs do have steep dose-response relationships and a narrow therapeutic margin and drug interactions can cause major problems, for example with antithrombotic, antidysrhythmic and anti-epileptic drugs, lithium and several antineoplastic and immunosuppressant drugs.

Ketersediaan
EBK-00231615.1/Gha-dPerpus PusatTersedia
Informasi Detail
Judul Seri
-
No. Panggil
615.1/Gha-d
Penerbit
Cairo : Faculty of Medicine Cairo University.,
Deskripsi Fisik
146 hlm
Bahasa
Indonesia
ISBN/ISSN
-
Klasifikasi
615.1
Tipe Isi
text
Tipe Media
e-book
Tipe Pembawa
-
Edisi
-
Subjek
Drug
drug interaction
farmakologis
Info Detail Spesifik
Electronic Version
Pernyataan Tanggungjawab
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Tidak tersedia versi lain

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