All the formulations were developed exclusively on a laboratory scale of the order of 1 kg maximum. For this reason, scale-up for production must therefore be checked and revised, as necessary. It is only in very exceptional cases that the formulations have been optimized by a systematic study involving a comparison between different excipients or by varying the amounts of excipients. Thus, the…
A recent article published in the New York Times quoted the astounding statistic that as many as 7,000–10,000 deaths in the United States can be attributed on an annual basis to prescription errors. Countless hospital days, loss of productivity, and an atmosphere of distrust of modern medicine all result from such errors. Many causes can be found for these mistakes; drugs with completely diff…