Everybody thinks it cannot happen to them. And yet, six million people die of cancer every year. Approximately every fourth citizen of a developed country will be stricken sometime during his life and approximately 400 new incidents emerge per 100,000 people annually. Once considered a mysterious disease, cancer has been eventually revealed to investigators (Trichopoulos and Hunter, 1996). Dise…
After over half a century of chemotherapy research, cancer remains one of the most difficult life-threatening diseases to treat, a consequence of factors which include limitations of animal models, tumour diversity, drug resistance and side effects of therapy. This introductory overview gives a brief perspective on the discovery of historical cytotoxic and anti-hormonal drugs, and then highligh…
Acute gout attacks are characterized by rapid onset of excruciating pain, swelling, and inflammation. The attack is typically monoarticular, most often affecting the first metatarsophalangeal joint (podagra), and then, in order of frequency, the insteps, ankles, heels, knees, wrists, fingers, and elbows. Attacks commonly begin at night, with the patient awakening with excruciating pain. Affecte…
Basic and clinical research provides a continuous flow of biomedical information that enables practitioners to use medications more effectively and safely. The editors, authors, and publisher of this book have made every effort to ensure accuracy of information provided. However, it is the responsibility of all practitioners to assess the appropriateness of published drug therapy information, e…
Malaria merupakan penyakit menular yang sangat berbahaya dapat menyebabkan kematian, terutama pada kelompok-kelompok yang mempunyai risiko tinggi seperti bayi, anak balita dan ibu hamil, serta kelompok usia produktif, sehingga secara langsung dapat menurunkan produktivitas kerja (Hasan, 2006). Malaria ditemukan hampir di seluruh bagian dunia, terutama di negara-negara yang beriklim tropis dan s…
The development of chemotherapy in the 1950’s and 1960’s resulted in curative therapeutic strategies for patients with hematologic malignancies and several types of advanced solid tumors. These advances confirmed the principle that chemotherapy could indeed cure cancer and provided the rationale for integrating chemotherapy into combined-modality programs with surgery and radiation therapy …